Reference of 1480-65-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1480-65-5, name is 5-Chloro-2-fluoropyridine. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of 5-bromo-2-(tert-butylthio)aniline (300 mg, 1 .2 mmol), 5-chloro-2-fluoropyridine (157 mg, 1 .2 mmol), Cs2C03 (782 mg, 2.4 mmol) in NMP (5 mL) was purged with N2 before heated to 140 ¡ãC for 8 h. The reaction mixture was then cooled down to room temperature. Water was added and the mixture was partitioned between EtOAc (50 mL) and water (15 mL). The layers were separated and the organic layer was washed with brine (20 mL), dried with Na2S04, and concentrated. The crude product was purified by flash chromatography (silica gel, 5-20percent EtOAc in petroleum ether) to give the title compound (100 mg, 24percent) as a yellow solid. LCMS (M+H)+: m/z = 371 .43.
According to the analysis of related databases, 1480-65-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; JOHNS, Brian Alvin; KAZMIERSKI, Wieslaw Mieczyslaw; DE LA ROSA, Martha Alicia; SAMANO, Vicente; (84 pag.)WO2017/195149; (2017); A1;,
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