Synthetic Route of 89284-61-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 89284-61-7, name is 4-Chloronicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of ethanolamine (0.60 mL, 10.0 mmol), 4-chloronicotinonitrile (1.38 g, 10.0 mmol) and diisopropylethylamine (1.74 mL, 10.0 mmol) in isopropanol was heated at reflux for 2.5 hours. It was cooled to room temperature and loaded on to a 5Og SCX-2 cartridge preconditioned with methanol. The cartridge was eluted with methanol and then with a 2M solution of ammonia in methanol. Collecting appropriate fractions followed by evaporation of solvents gave the title compound as a beige solid (1.20 g, 74%). 1H NMR (d6-DMSO, 400MHz) 8.40 (s, IH), 8.21 (d, J = 6.3 Hz, IH), 6.94 (bs, IH), 6.77(d, J = 6.3 Hz, IH), 4.84 (bs, IH), 3.55 (t, J = 6.0 Hz, 2H), 3.31 (dt, J = 6.0 Hz, 6.0 Hz, 2H). [00301] Step 2: 4-(2-Triisopropylsilanyloxy-ethylamino)-nicotinonitrile
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 89284-61-7, 4-Chloronicotinonitrile.
Reference:
Patent; GENENTECH, INC.; WO2008/67481; (2008); A1;,
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