In 2022,Shi, Zhaojiang; Lu, Hao-Kuan; Li, Nan; Yuan, Yaofeng; Li, Zhen; Ye, Ke-Yin published an article in Organic Chemistry Frontiers. The title of the article was 《Electrochemical oxidative dearomatization of 2-arylthiophenes》.SDS of cas: 197958-29-5 The author mentioned the following in the article:
A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC6H4, 2-pyridyl, etc.; R1 = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5SDS of cas: 197958-29-5)
2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. SDS of cas: 197958-29-5