Shimeno, Hiroshi’s team published research in Journal of Enzyme Inhibition in 2 | CAS: 18437-58-6

Shimeno, Hiroshi published the artcileInhibition of rat liver tryptophan pyrrolase activity and elevation of brain tryptophan concentration by administration of DL-α-amino-β-pyridinepropanoic acid (pyridylalanine) analogs, Computed Properties of 18437-58-6, the publication is Journal of Enzyme Inhibition (1987), 2(1), 57-66, database is CAplus and MEDLINE.

Single doses of DL-α-amino-β-(2-pyridine)propanoic acid (2-PA, 100 mg/kg) decreased the holoenzyme and apoenzyme activities of rat liver tryptophan pyrrolase (TP) and increased brain tryptophan, serotonin (5-HT) and 5-hydroxyindole-3-ylacetic acid concentrations 2-PA had no inhibitory effect on either of the enzyme activities in vitro, but its expected metabolites were effective. Single doses of DL-α-amino-β-(3-pyridine)propanoic acid (3-PA, 100 mg/kg) decreased only the holoenzyme activity and elevated brain tryptophan and its metabolites levels in rats. 3-PA and its metabolite, 3-pyridylpyruvate, inhibited only the holoenzyme activity in vitro. DL-α-Amino-β-(4-pyridine)propanoic acid (4-PA) caused changes in liver TP (holo- and apoenzyme forms) activity and brain tryptophan concentration only after repeated administration (100 mg/kg/day). 4-PA was a weak inhibitor of the holoenzyme, but its metabolites apparently inhibited the holo- and apoenzyme activities in vitro. These findings suggest that PA analogs (and(or) their metabolites) increased brain tryptophan (and hence 5-HT synthesis) by directly inhibiting liver TP activity.

Journal of Enzyme Inhibition published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C8H11NO, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem