Shirkhedkar, Atul A. published the artcileExploring an experimental combination of analytical quality by design and green analytical chemistry approaches for development of HPTLC densitometric protocol for the analysis of barnidipine hydrochloride, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Biomedical Chromatography (2022), 36(1), e5244, database is CAplus and MEDLINE.
An exptl. combination of anal. quality by design and green anal. chem. approaches is introduced to develop an high-performance thin-layer chromatog. (HPTLC) approach to quantify barnidipine hydrochloride in the pharmaceutical matrix. The anal. quality by design approach was introduced to green anal. chem. to enhance protocol knowledge while ensuring efficiency and reducing environmental impacts, energy consumption and analyst visibility. This anal. approach was systematically addressed by exploring failure mode effect anal., risk assessment and optimization design. Subsequently, a screening of primary variables was performed to select the aptest proportion of solvents in the mobile phase resulting from the principles of green anal. chem. Failure mode effect anal. and a risk assessment study were attempted to estimate the critical method parameters (CMPs). The influence of the CMPs on critical anal. attributes, i.e. retention factor and peak area, was assessed through a screening design. A response surface methodol. was then executed for the critical anal. attributes as a concern of the determined CMPs, and the conditions for excellent resolution were determined using a desirability procedure. The established protocol was validated in compliance with the International Conference on Harmonization guideline Q2(R1) and showed excellent specificity and sensitivity.
Biomedical Chromatography published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C12H10O4S, Application of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem