In 2018,Shu, Bing; Cao, Jiaojiao; Kuang, Guotao; Qiu, Jun; Zhang, Meiling; Zhang, Yan; Wang, Mingxue; Li, Xiaoya; Kang, Shuangshuang; Ou, Tian-Miao; Tan, Jia-Heng; Huang, Zhi-Shu; Li, Ding published 《Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation》.Chemical Communications (Cambridge, United Kingdom) published the findings.Formula: C7H9NO The information in the text is summarized as follows:
We synthesized a series of acridone derivatives for specific binding ligands of i-motifs. Subsequent evaluations showed that B19 (I) could selectively bind to and stabilize the c-myc promoter i-motif without significant binding to the G-quadruplex and duplex DNA. This caused down-regulation of c-myc transcription and expression, resulting in tumor cell apoptosis. In the part of experimental materials, we found many familiar compounds, such as 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Formula: C7H9NO