In 2022,Siddiqa, Ayesha; Zubair, Muhammad; Bilal, Muhammad; Rasool, Nasir; Qamar, Muhammad Usman; Khalid, Aqsa; Ahmad, Gulraiz; Imran, Muhammad; Mahmood, Sajid; Ashraf, Ghulam Abbas published an article in Pharmaceuticals. The title of the article was 《Synthesis of Functionalized N-(4-Bromophenyl)furan-2-carboxamides via Suzuki-Miyaura Cross-Coupling: Anti-Bacterial Activities against Clinically Isolated Drug Resistant A. baumannii, K. pneumoniae, E. cloacae and MRSA and Its Validation via a Computational Approach》.HPLC of Formula: 1692-25-7 The author mentioned the following in the article:
N-(4-Bromophenyl)furan-2-carboxamide I [R = Br] was synthesized by the reaction furan-2-carbonyl chloride and 4-bromoaniline in the presence of Et3N in excellent yields of 94%. The carboxamide I [R = Br] was arylated by employing triphenylphosphine palladium as a catalyst and K3PO4 as a base to afford N-(4-bromophenyl)furan-2-carboxamide analogs I [R = 4-MeC6H4, 4-MeOC6H4, 4-ClC6H4, etc.] in moderate to good yields (43-83%). Furthermore, in vitro anti-bacterial activities of the resp. compounds against clin. isolated drug-resistant bacteria A. baumannii, K. pneumoniae, E. cloacae and S. aureus was investigated. The mol. I [R = Br] was found to be the most effective activity against these bacteria, particularly NDM-pos. bacteria A. baumannii as compared to various com. available drugs. Docking studies and MD simulations further validated it, expressing the active site and mol. interaction stability. After reading the article, we found that the author used Pyridin-3-ylboronic acid(cas: 1692-25-7HPLC of Formula: 1692-25-7)
Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 1692-25-7