Simple exploration of 1-(3,5-Dichloropyridin-4-yl)ethanol

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1254473-66-9, its application will become more common.

Synthetic Route of 1254473-66-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1254473-66-9, name is 1-(3,5-Dichloropyridin-4-yl)ethanol. A new synthetic method of this compound is introduced below.

A solution of 1- (3,5-dichloropyridin-4-yl) ethanol (II) (6 g, 31.24 mmol) in dichloromethane (DCM, 50 ml) was added portionwise over 10 min. PCC, 10.1 g, 46.86 mmol) at room temperature for 10 h.The insoluble matter was removed by filtration, and the residue was washed three times with DCM. The combined organic layers were concentrated to a crude product.Purification by silica gel column chromatography (petroleum ether: ethyl acetate = 20: 1) gave 5.10 g of colorless, turbid oil; Yield 85%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1254473-66-9, its application will become more common.

Reference:
Patent; Sichuan University; Wu, Yong; Hai, Li; Lei, Fan; Li, XiaoCen; (7 pag.)CN103819396; (2016); B;,
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