With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.127561-18-6, name is 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, molecular formula is C10H12F3N3, molecular weight is 231.22, as common compound, the synthetic route is as follows.HPLC of Formula: C10H12F3N3
Add 4- (6-TRIFLUOROMETHYL-2-PYRIDYL) piperazine (46 mg, 0. 2 mmol) to a solution of 4- [6-CHLORO-2- (3-CHLOROPHENYL) PYRIMIDIN-4-YL] morpholine (62 mg, 0. 2 mmol), PD2 (dba) 3 (18 mg, 0. 02 MMOL), and BINAP (17 mg, 0. 02 mmol) in toluene (2 mL) under nitrogen, followed by t-BuOK (45 mg, 0. 4 mmol). Stir the mixture at 90C for 8 hours, dilute with aqueous ammonium chloride, and extract with EtOAc (3 x 10 mL). Dry (MGS04) the combined extracts and concentrate under reduced pressure. Purify the residue using flash chromatography on silica gel (50% hexane/50% ether) to give the title compound. MS 505 (M+ 1).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,127561-18-6, 1-(6-(Trifluoromethyl)pyridin-2-yl)piperazine, and friends who are interested can also refer to it.
Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem