In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 106850-34-4, name is Imidazo[1,2-a]pyridine-6-carbonitrile, the common compound, a new synthetic route is introduced below. name: Imidazo[1,2-a]pyridine-6-carbonitrile
Nitrogen was bubbled for five minutes into a stirred mixture of 2-chloro-4- methoxypyrimidine (1.14 g, 7.9 mmol), imidazo[1 ,2-a]pyridine-6-carbonitrile (Preparation 1 , 0.75 g, 5.2 mmol), potassium carbonate (1.45 g, 10.5 mmol) and triphenylphosphine (0.55 g, 2.1 mmol) in 1 ,4-dioxane (10 mL) and ethanol (5 mL) in a microwave vessel. Then palladium (II) acetate (0.24 g, 1.1 mmol) was added and the vessel was sealed and subjected to microwave irradiation for 2 hours at 150 C. The reaction was repeated 5 further times under the same conditions and the six experiments were combined and the solvent was evaporated. The residue was taken up in a mixture of ethyl acetate and water and filtered to remove an insoluble black solid. The organic layer was separated and extracted with 2M aqueous hydrochloric acid (3 x 80 mL). The combined aqueous layer was washed with diethyl ether and then treated with solid sodium hydrogencarbonate until a pH of approximately 6 was reached. The solid that formed was filtered and dried in vacuum to give a first crop of the title compound (2.65 g). The insoluble black solid was treated with 2M aqueous hydrochloric acid (2 x 60 mL) and filtered. The aqueous solution was treated with solid sodium hydrogencarbonate until a pH of approximately 6 was reached. The solid that formed was filtered and dried in vacuum to give a second crop of the title compound (0.77 g). Total yield = 3.42 g (43%).LRMS (m/z): 252 (M+1)+.1H-NMR delta (DMSO-cfe): 4.08 (s, 3H), 6.88 (d, 1 H), 7.76 (dd, 1 H), 7.95 (dd, 1 H), 8.63 (s, 1 H), 8.67 (d, 1 H), 10.39 (bs, 1 H).
The synthetic route of 106850-34-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ALMIRALL, S.A.; EASTWOOD, Paul Robert; GONZALEZ RODRIGUEZ, Jacob; BACH TANA, Jordi; PAGES SANTACANA, Lluis Miquel; TALTAVULL MOLL, Joan; CATURLA JAVALOYES, Juan Francisco; MATASSA, Victor Giulio; WO2011/76419; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem