Electric Literature of 1072-97-5, Adding some certain compound to certain chemical reactions, such as: 1072-97-5, name is 5-Bromopyridin-2-amine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1072-97-5.
5-bromopyridin-2-amine (0.5 g, 2.89 mmol), cyclopropylboronic acid (0.49 g, 5.78 mmol) and K3PO4 (1.84 g, 8.67 mmol) were combined in a mixture of toluene : water (4:1, 10 ml) and the mixture was degassed for 20 minutes with argon gas. To the reaction mixture, palladium acetate (0.032 g, 0.144 mmol) and tricyclo hexyl-phosphine (0.081 g, 0.289 mmol) were added and degassing was continued for another 10 minutes. The reaction mixture was heated in a sealed tube at 100 C for 16 hours. The reaction mixture was diluted with water (15 ml) and extracted with ethyl acetate (2 x 15 ml). The combined organic layers were washed with brine (15 ml), dried over anhydrous Na2S04 and concentrated under reduced pressure. The residue was purified by silica gel chromatography to afford the title compound (0.3 g, 77%) as a solid. 1H NMR (400 MHz, DMSO-d6): d 0.49-0.56 (m, 2H), 0.75-0.83 (m, 2H), 1.70-1.77 (m, 1H), 5.65 (s, 2H, -NH2), 6.36 (d, / = 8.4 Hz, 1H), 7.04 (dd, 7 = 8.4 Hz, 2.0 Hz, 1H), 7.74 (d, / = 1.6 Hz, 1H). LCMS: m/z =135.2 [M+l]
According to the analysis of related databases, 1072-97-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS, INC.; WILSON, Jonathan, E.; BRUCELLE, Francois; LEVELL, Julian, R.; (153 pag.)WO2019/161162; (2019); A1;,
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