Simple exploration of 1,1′-Thiocarbonylbis(pyridin-2(1H)-one)

The synthetic route of 102368-13-8 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 102368-13-8, name is 1,1′-Thiocarbonylbis(pyridin-2(1H)-one), the common compound, a new synthetic route is introduced below. name: 1,1′-Thiocarbonylbis(pyridin-2(1H)-one)

(c) N-(2,4-Difluoro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide A mixture of N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide (570 mg, 2.35 mmol), 1,1′-thiocarbonyldi-2(1H)-pyridone (550 mg, 2.35 mmol) and dioxane (20 mL) is stirred at reflux overnight. The reaction mixture is concentrated, diluted with DCM, filtered through a pad of silica gel and the filtrate is concentrated to give the title compound. Yield: 440 mg (65%). Rf=0.80 (silica gel, DCM:EtOH 95:5).

The synthetic route of 102368-13-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2012/214786; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem