In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1122-43-6, name is 2,6-Dimethyl-3-hydroxypyridine, the common compound, a new synthetic route is introduced below. name: 2,6-Dimethyl-3-hydroxypyridine
Example 66; (3R)-1-{2-[(2,6-Dimethylpyridin-3-yl)oxy]ethyl}-3-{[2-piperidin-1-yl-2-(2-thienyl)propanoyl]oxy}-1-azoniabicyclo[2.2.2]octane bromide (Isomer 1); a) 3-(2-Bromoethoxy)-2,6-dimethylpyridine; 2,6-Dimethylpyridin-3-ol (2 g) in dry DMF (20 mL) under nitrogen was treated with sodium hydride (1.234 g). After the initial effervescence ceased 1,2-dibromoethane (6.10 g) was added in one portion causing an exotherm to 40 C. The mixture was stirred at room temperature overnight, diluted with water (100 mL), and the products extracted into ether (3×75 mL). The dried extracts were concentrated to dryness, and the residue purified on silica gel eluting with ether/dichloromethane (1:1). The subtitled compound was isolated as an oil (1.2 g).1H NMR (400 MHz, CDCl3) delta 6.98 (1H, d), 6.92 (1H, d), 4.26 (2H, t), 3.65 (2H, t), 2.47 (6H, d).
The synthetic route of 1122-43-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ford, Rhonan; Mete, Antonio; Millichip, Ian; Teobald, Barry; US2010/113510; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem