Electric Literature of 1241752-31-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1241752-31-7, name is 5-Bromo-2-ethoxy-3-methoxypyridine. A new synthetic method of this compound is introduced below.
d. Preparation of Compound To a solution of known 2-ethoxy-3-methoxy-5-bromopyridine (100 mg, 0.34 mmol) in 1,4- dioxane ( 3.0 ml), trimethyl boroxine (80 mg, 0.69 mmol) and Pd(dppf)Cl2 (56.3 mg, 0.069 mmol) was added, followed by CsC03 (300 mg, 0.92 mmol). The mixture was degassed for 30 minutes, and then heated to 90 C for 16 hr. After cooling, the crude mixture was filtered on celite and extracted with EtOAc (3x), washed with NaCl, the organic layer was dried with Na2S04 and concentrated to give crude product . The crude product was purified by ISCO flash chromatography using 10% EtOAc in hexane, giving 50 mg compound (Yield: 84%). ‘H NMR (300 MHz, CDC13) delta: 7.52 (s, I H), 6.84 (s, IH), 4.45 (q, 2H), 3.82 (s, 3H), 2.21 (s, 3H), 1.39 (t, 3H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1241752-31-7, 5-Bromo-2-ethoxy-3-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem