Related Products of 128071-79-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.128071-79-4, name is 4-Bromo-2-fluoro-3-methylpyridine, molecular formula is C6H5BrFN, molecular weight is 190.013, as common compound, the synthetic route is as follows.
A mixture of 4-bromo-2-fluoro-3-picoline (1.90 g, 10 mmol, 1.0 eq), pyrazole (1.36 g, 20 mmol, 2.0 eq) and potassium carbonate (2.80 g, 20 mmol, 2.0 eq) in DMSO (20 mL, 0.5 M) was stirred at 70 C. After 16 h, the reaction mixture was added to brine and extracted with EtOAc (3x). The combined extracts were washed with brine, dried (MgS04), filtered and concentrated. The crude material was purified using chromatography on silica gel (0-50% EtO Ac/hexanes) to provide the title compound as a white crystalline solid (2.23 g, 94%). NMR (400 MHz, CDCl3) d 8.12 (d, J= 5.1 Hz, 1H), 8.09 (d, J= 2.2 Hz, 1H), 7.75 (d, J= 1.3 Hz, 1H), 7.51 (d, j= 5.2 Hz, 1H), 6.45 (dd, j= 2.3, 1.9 Hz, 1H), 2.56 (s, 3H). ES-MS [M+H]+ = 238.3.
The chemical industry reduces the impact on the environment during synthesis 128071-79-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; VANDERBILT UNIVERSITY; LINDSLEY, Craig W.; CONN, P. Jeffrey; ENGERS, Darren W.; ENGERS, Julie L.; BENDER, Aaron M.; LONG, Madeline; (120 pag.)WO2019/241467; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem