13534-99-1 ,Some common heterocyclic compound, 13534-99-1, molecular formula is C5H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
2-Amino-3-bromopyridine (VII-41) (5.00 g, 28.9 mmol) was dissolved in ethanol (100 mL), sodium hydrogencarbonate (3.64 g, 43.3 mmol) and 2-chloroacetaldehyde (7.1 mL, 43 mmol) were added, and the mixture was stirredunder refluxing with heating for 4 hr. The mixture was allowed to cool, and the solvent was evaporated under reducedpressure. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed withsaturated brine, dried over anhydrous sodium sulfate, and filtered. The solvent was evaporated under reduced pressure.The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate = 70:30 ? 40:60) to give 8-bromoimidazo[1,2-a]pyridine (VII-42) (yield 5.71 g, quantitative
According to the analysis of related databases, 13534-99-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; WATANABE, Atsushi; SATO, Yuuki; OGURA, Keiji; TATSUMI, Yoshiyuki; (331 pag.)EP3351533; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem