With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14667-47-1, name is Methyl 2-aminonicotinate, molecular formula is C7H8N2O2, molecular weight is 152.15, as common compound, the synthetic route is as follows.Computed Properties of C7H8N2O2
Preparation Example A-3 2-Amino-5-nitro-nicotinic acid methyl ester 2-Amino-nicotinic acid methyl ester (1.00g, 6.57mmol) described in Preparation Example A-2 was dissolved at 0C in a mixed solution of nitric acid (0.7mL) and sulfuric acid (2.6mL), which was stirred at 0C for 40 minute and at room temperature for 19 hours, then, further stirred at 70C for 4 hours. A saturated aqueous solution of sodium bicarbonate was added to the reaction solution at 0C, which was extracted with ethyl acetate and tetrahydrofuran, the organic layer was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated in vacuo. Methanol was added to the residue, the precipitated solid was filtered to obtain the title compound (459mg, 2.33mmol, 35%) as a white solid. 1H-NMR Spectrum (DMSO-d6) delta (ppm): 3.86 (3H, s), 8.14 (1 H, brs), 8.62 (1 H, brs), 8.68 (1 H, d, J=2.7Hz), 9.04 (1 H, d, J=2.9Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,14667-47-1, Methyl 2-aminonicotinate, and friends who are interested can also refer to it.
Reference:
Patent; Eisai R&D Management Co., Ltd.; EP1782811; (2007); A1;,
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