Application of 165547-79-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 165547-79-5, name is 4-Chloro-3-nitro-2(1H)-pyridinone. This compound has unique chemical properties. The synthetic route is as follows.
Synthesis of 4-chloro-l-methyI-3-nitropyridin-2(lH)-one ^N^O MuthetaIota/NaH/D F ri^ ^ -NO, Stepl NO, To a stirred solution of 4-chloro-3-nitropyridin-2(l H)-one (3.0 g, 17 mmol) in N,N- dimethyiformarnide (50 mL) was added sodium hydride (60% w/w, 1.0 g, 25.5 mmol) in batches at 0C. The mixture was stirred at room temperature for 30 minutes. ‘Then iodomethane (2.9 g, 20.4 mmol) was added dropwise to the above solution at room temperature .The resultant solution was stirred at room temperature for 12 hours. Once starting material was consumed, the reaction mixture was quenched with ice water (100 mL) at 0~10C, and extracted with ethyl acetate(100 mL x 3).The organic phase was washed with brine (100 mL x 2), dried over anhydrous sodium sulfate, filtered and concentrated to give a residue, ‘The residue was purified by column chromatography (silica gel, dichloromethane/methanol = 10: 1) to give 4-chloro-l- methyl-3- nitropyridin-2( 1 H)-one (3 g, 94%) as a yellow solid. LRMS (M + EpsilonGamma) m/z; calcd 188.0; found 188.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 165547-79-5, 4-Chloro-3-nitro-2(1H)-pyridinone.
Reference:
Patent; CONSTELLATION PHARMACEUTICALS; ALBRECHT, Brian, K.; AUDIA, James, Edmund; COOK, Andrew, S.; DAKIN, Les, A.; DUPLESSIS, Martin; GEHLING, Victor, S.; HARMANGE, Jean-Christophe; NAVESCHUK, Christopher, G.; VASWANI, Rishi, G.; WO2013/120104; (2013); A2;,
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