In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 19235-89-3, name is 4-Chloropyridine-2-carbonitrile, the common compound, a new synthetic route is introduced below. Formula: C6H3ClN2
[Referential Example 114]; 4-Methylthiopyridine-2-carbonitrile; Sodium thiomethoxide (1.01 g) was added to 4-chloropyridine-2-carbonitrile (2.00 g) obtained from Referential Example 113 in N,N-dimethylformamide (20 mL) at 0C, followed by stirring for 2 hours. The reaction mixture was partitioned between water and ethyl acetate. The organic layer was dried over sodium sulfate anhydrate, followed by filtration. The solvent was evaporated under reduced pressure. The residue was purified through silica gel column chromatography (hexane – ethyl acetate), to thereby give the title compound as a solid (1.96 g, 90%).1H-NMR(400MHz,CDCl3)delta: 2.53(3H,s), 7.26-7.27(1H,m), 7.45-7.46(1H,m), 8.45-8.46(1H,m). MS(EI)m/z: 150(M+) .
The synthetic route of 19235-89-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1591443; (2005); A1;,
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