Reference of 1945-84-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1945-84-2, name is 2-Ethynylpyridine. A new synthetic method of this compound is introduced below.
General procedure: To a stirred solution of alkyne (1 mmol) in CH2Cl2 (3 mL), TsNBr2 (1.2 mmol) and DBU (1.2 mmol) was added. The progress of the reaction was monitored by TLC. After the completion of the reaction sodium thiosulfate (200 mg) was added to the reaction mixture and further stirred for 5 min. The reaction mixture was washed with water and extracted with ethyl acetate. The organic layer was separated and dried over Na2SO4 and concentrated in vacuo. Purification of the crude product by flash chromatography on silica gel (230-400mesh) with petroleum ether as eluent gave the desired product.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1945-84-2, 2-Ethynylpyridine, and friends who are interested can also refer to it.
Reference:
Article; Rajbongshi, Kamal Krishna; Hazarika, Debojit; Phukan, Prodeep; Tetrahedron; vol. 72; 29; (2016); p. 4151 – 4158;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem