As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17117-13-4, name is 2-Bromo-4-ethoxypyridine, molecular formula is C7H8BrNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 2-Bromo-4-ethoxypyridine
7.05.01. 2-(3, 5-Bis-(4-fluoro-phenyl)-(l, 2, 4) triazol-l-yl)-l-(4-(4-ethoxy-pyridin-2-yl)- piperazin- 1 -yl)-ethanone 17 mg BINAP and 24 mg tris-(dibenzylidenacetone)palladium(0) were added to 255 mg casiumcarbonate, 65 mg 2-brom-4-ethoxy-pyridine and 100 mg 2-(3, 5-Bis-(4-fluoro-phenyl)-(l, 2, 4) triazol-l-yl)-l-piperazin-l-yl-ethanone in 10 mL toluole under nitrogen atmosphere. The reaction was refluxed for 4 days. The mixture was filtered and the filtrate was evaporated. The residue was purified by HPLC. Rt: 1.22 min (method B), (M+H)+: 505
With the rapid development of chemical substances, we look forward to future research findings about 17117-13-4.
Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; GRAUERT, Matthias; BISCHOFF, Daniel; DAHMANN, Georg; KUELZER, Raimund; RUDOLF, Klaus; WO2013/107761; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem