Application of 727356-19-6, Adding some certain compound to certain chemical reactions, such as: 727356-19-6, name is 2-Bromo-6-(chloromethyl)pyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 727356-19-6.
Compound 7 (0.15 g, 0.57 mmol) was dissolvedin N,N-dimethylacetamide (2 mL) and sodium hydride (0.017 g, 0.7 mmol) added. The mixture was stirred at room temperature for 20 minutes. Then compound 15(0.2 g, 0.77 mmol) was added and the mixture was heated at ~ 60C in a sand-bath for 2 h. The mixture was diluted with ethyl acetate (40 mL) and brine (15 mL).The organic phase was separated, dried over Na2SO4, filtered and the solvents removed. The residue was purified by chromatography on silica using dichloromethane to elute excess benzyl chloride, followed by dichloromethane/acetone (95/5) to afford 18 as yellow oil (0.2 g, 82 %). 1H-NMR (400 MHz, CDCl3): delta= 1.40 (s, 9H), 2.86 (t, 2H), 4.48 (t, 2H), 5.25 (s, 2H), 6.88 (d, 1H), 7.17 (d, 1H), 7.32 (d, 1H), 7.45 (t, 1H), 7.58 (t, 1H), 7.74 (d, 1H).
According to the analysis of related databases, 727356-19-6, the application of this compound in the production field has become more and more popular.
Reference:
Article; Kroth, Heiko; Sreenivasachary, Nampally; Hamel, Anne; Benderitter, Pascal; Varisco, Yvan; Giriens, Valerie; Paganetti, Paolo; Froestl, Wolfgang; Pfeifer, Andrea; Muhs, Andreas; Bioorganic and Medicinal Chemistry Letters; vol. 26; 14; (2016); p. 3330 – 3335;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem