Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10386-27-3, name is 2-Bromoisonicotinonitrile. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromoisonicotinonitrile
To a solution of 2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[4,5-c] pyridine (I- 23.4) (40 mg, 0.2 mmol) in DMF (2 mL) was added 2-bromoisonicotinonitrile (54 mg, 0.3 mmol), DIEA (52 mg, 0.4 mmol). The mixture was heated to 1000C and stirred for 16 h. The mixture was cooled to room temperature and poured into water. The mixture was extracted with EtOAc. The combined organic phase was dried over anhydrous Na2SO4 and concentrated. The residue was purified by preparative TLC to afford 2-(2- (pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)isonicotinonitrile (10 mg, 17percent) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.67 (d, IH), 8.25 (d, IH), 8.03 (d, IH), 7.75 (t, IH), 7.30 (t, IH), 6.81 (s, IH), 6.75 (d, IH), 4.52 (s, 2H), 4.07 (t, 2H), 2.91 (t, 2H); LC/MS: m/e = 304 (M+H)+.
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Reference:
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem