Related Products of 1195189-83-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1195189-83-3, name is 2-Chloro-3-methylisonicotinonitrile, molecular formula is C7H5ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
In a pre-dried flask, Dl (12.6 g; 82.9 mmol) was dissolved in Et2O (anhydrous) (200 ml) and under N2 (gas) protection, bro mo methyl magnesium (100 ml) was added slowly. The reaction mixture was stirred at room temperature overnight and then poured slowly into a mixture of ice-H2O (600 ml) and 37% aqueous HCl (100 ml). The reaction mixture was stirred and extracted with Et2O (200 ml x 4). The combined organic phases were then washed with brine, dried (Na2SO4), filtered and the solvent evaporated in vacuo. Yield: 11.6 g of D2 (88 % pure product).
According to the analysis of related databases, 1195189-83-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2009/135944; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem