Related Products of 116308-38-4, Adding some certain compound to certain chemical reactions, such as: 116308-38-4, name is 2-Formylisonicotinonitrile,molecular formula is C7H4N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 116308-38-4.
Triethylamine (2.2 ml, 15 mmol) was added to a mixture of (3-oxo-1,3-dihydro-isobenzofuran-1-yl)-phosphonic acid dimethyl ester (i)(2.4 g, 10.2 mmol) and (iid) (10.2 mmol) in tetrahydrofuran (10 ml). The reaction mixture was stirred for over 12 hours at 25C and concentrated in vacuo to yield 2-[3-oxo-3H-isobenzofuran-(1£,Z)-ylidenemethyl]-isonicotinonitrile (iii-int) as a red solid which was taken towards the next step without purification. (c) 2-(3-Oxo-3H-isobenzofuran-1-ylidenemethyl)-isonicotinonitrile (iii-int)To a cooled suspension (ca 0C) of [(3-Oxo-1,3-dihydro-isobenzofuran-1-yl)-phosphonic acid dimethyl ester] phosphonate (i)(8.0g, 33.0mmol) in THF (400mL) was added crude 2-formyl-isonicotinonitrile (iid)(30.0mmol) followed by triethylamine (6.2mL, 33.0mmol). The mixture was stirred for 30 minutes at 0C and then allowed to warm overnight.The reaction mixture was then evaporated in vacuo, the resultant solid was then washed with ethyl acetate (2 x 50ml_), methanol (1x 15mL) and then diethyl ether (2x 20mL). Two peaks were detected in LC-MS analysis, the desired product; m/z (LC-MS, ESP), RT=4.27mins, (M+H)=249.0, and an impurity peak (approx 40%)RT=4.47mins M+H 194). This material used without need for any purification.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 116308-38-4, 2-Formylisonicotinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; KUDOS PHARMACEUTICALS LIMITED; WO2006/21801; (2006); A1;,
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