Reference of 21948-75-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 21948-75-4, name is 2-(Methylsulfinyl)pyridine, molecular formula is C6H7NOS, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: p-NO2DPPA (91.3 mg, 0.25 mmol) and DABCO (28.0 mg, 0.25 mmol) were added to a solution of the sulfoxide (0.10 mmol) in toluene (0.35 mL). After stirring for 2 h at reflux, the mixture was diluted with AcOEt/n-hexane (1:5) (30 mL). Then, the mixture was washed with saturated aqueous NaHCO3 (25 mL) and brine (25 mL), and dried over Na2SO4. Concentration of the solvent in vacuo followed by purification of the residue on a silica gel column (AcOEt:n-Hexane 1:5-0:1) gave the desired alpha-azido sulfide.
According to the analysis of related databases, 21948-75-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Ishihara, Kotaro; Shioiri, Takayuki; Matsugi, Masato; Tetrahedron Letters; vol. 58; 41; (2017); p. 3932 – 3935;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem