Related Products of 1136-52-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. This compound has unique chemical properties. The synthetic route is as follows.
A mixture of alpha4,3-O-isopropylidene pyridoxine (1, 0.10 g, 0.48 mmol, 1.00 eq.), 2,3,4,6-tetra-O-acetyl-[13C6]-alpha-d-glucopyranosyl bromide (24, 0.23 g, 0.57 mmol, 1.20 eq.) and molecular sieves (4 A) in dry dichloromethane (5 mL) was stirred under argon atmosphere at rt for 1 h. The reaction was cooled to 0 C, AgOTf (0.36 g, 1.43 mmol, 3.00 eq.) and NIS (0.32 g, 1.43 mmol, 3.00 eq.) were added and the reaction mixture was allowed to reach rt overnight. The mixture was diluted with dichloromethane (25 mL) and filtered through a pad of celite. Afterwards, the filtrate was washed with Na2S2O3 (10 % v/v in water, 30 mL) and the aqueous phase extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with distilled water (1 x 50 mL), brine (1 x 50 mL) and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product subjected to column chromatography using SiO2 (pentane/ethyl acetate 1/1 to 1/4, gradient elution) followed by Sephadex (methanol, isocratic) to afford the glycoside (25, 85.8 mg, 0.15 mmol, 33 %).
According to the analysis of related databases, 1136-52-3, the application of this compound in the production field has become more and more popular.
Reference:
Article; Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael; Carbohydrate Research; vol. 489; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem