Adding a certain compound to certain chemical reactions, such as: 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2,3-Dichloro-5-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. Safety of 2,3-Dichloro-5-(trifluoromethyl)pyridine
Example 6 : Preparation of 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-phenylethanamine; Preparation of 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl-1-phenylethanone; To a suspension of 2.6 g (0.065 mol) of sodium hydride 60% in dimethoxyethane at room temperature is added 3.4 mL (0.029 mol) of acetophenone. After 45 min. , 5.55 mL ( 0.038 mol) of 2,3-dichloro-5-(trifluoromethyl)pyridine is added. After 25 min., the reaction mixture is poured over 100mL of hydrochloric acid 1N, extracted twice with 100mL of ethyl acetate. The organic phase is washed twice 100 mL of water, dried over magnesium sulfate, filtered and concentrated to provide 15g of crude material which is purified over a column of silica by using a mixture of heptane and ethyl acetate as eluent, to yield to 5.74 g of desired product 2-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]-1-phenylethanone (74%). RMN 1H delta (ppm) 8,73 ; (1H, s) ; 7,95 (1H, s) ; 7,45 (2H, m) ; 7,42 (2H, m) ; 4,75 (2H, s).
The synthetic route of 69045-84-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Bayer CropScience S.A.; EP1548007; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem