In an article, author is Taha, Muhammad, once mentioned the application of 2459-09-8, Application In Synthesis of Methyl isonicotinate, Name is Methyl isonicotinate, molecular formula is C7H7NO2, molecular weight is 137.136, MDL number is MFCD00006427, category is pyridine-derivatives. Now introduce a scientific discovery about this category.
Antiglycation and antioxidant potential of novel imidazo[4,5-b]pyridine benzohydrazones
A series consisting of 30 novel imidazo[4,5-b]pyridine benzohydrazones have been synthesized and evaluated for their antiglycation activity as well as their antioxidative potential. The synthetic part involves a 3-step reaction in which a pyridine diamine was being converted into a imidazo[4,5-b]pyridine, which was then subjected through another reaction to yield benzohydrazide. Subsequently, the attained benzohydrazide of imidazo[4,5-b]pyridine was used to synthesize the target molecules after treating them with the appropriate benzohydrazone derivatives. The derivatives were evaluated for the antiglycation and antioxidant activities. Result obtained showed that di and trihydroxy substituted compounds showed good activity with compound 25 (140.16 +/- 0.36 mu M) having the most potent antiglycation activity, which is twice lower than Rutin. The results also showed certain correlation between antiglycation activities with DPPH radical scavenging model as well as FRAP which indicated the participation of antioxidative effect in inhibiting glycation activity. (C) 2015 The Authors. Published by Elsevier B.V.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem