Electric Literature of 21427-62-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 21427-62-3 as follows.
To a solution of 129.2 g (0.69 mol) of 2,5-dichloro-3-nitropyridine in 1300 ml of dioxane is added 26 0 g of Raney-nickel, that has previously been washed with ethanol. This mixture is then hydrogenated with hydrogen under normal pressure at 20-35 C. After uptake of 20% of the theoretical amount of hydrogen, another 30 g of washed Raney-nickel catalyst are added. After hydrogenating for 22 hours, the catalyst is filtered off, the solvent is evaporated and the residue is crystallized from hexane/ ethyl acetate. Thus, 84.9 g of 3-amino-2,5-dichloropyridine (78% of the theory) are obtained, which melts at 129-132 C.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,21427-62-3, its application will become more common.
Reference:
Patent; Ciba-Geigy Corporation; US4935051; (1990); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem