In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 38496-18-3, name is 2,6-Dichloronicotinic acid, the common compound, a new synthetic route is introduced below. SDS of cas: 38496-18-3
(a) 19.1 g (0.1 mole) of 2,6-dichloronicotinic acid [Guthzeit and Laska, J. pr. Ch. 58 [2], 425 (1898)] are suspended in 250 ml of methanol and, while stirring and cooling with ice, hydrogen chloride gas is introduced until the mixture is saturated. The reaction mixture is allowed to stand for 48 hours at room temperature and subsequently heated for 3 hours to reflux temperature. It is then evaporated to dryness in a high vacuum at 40 C and the residue is dried in a high vacuum at 40 C. The brown crystalline product is recrystallized from ether-pentane to yield methyl 2,6-dichloronicotinate with a melting point of 53-54 C.
The synthetic route of 38496-18-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ciba-Geigy Corporation; US4089960; (1978); A;,
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