With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.55676-22-7, name is 3-Acetyl-6-chloropyridine, molecular formula is C7H6ClNO, molecular weight is 155.5816, as common compound, the synthetic route is as follows.Product Details of 55676-22-7
To a 500 ml flask was added 6-chloro-3-acetylpyridine (18.7 g, 0.12 mol)P-cresol (14.26 g, 0.132 mol) and cesium carbonate (39 g, 0.12 mol)And DMF (300 ml) solvent.Heating reflux,After 1h, stop heating and cooling. The reaction solution was poured into excess water, stirred to precipitate a solid,filter. The crude product was recrystallized from ethyl acetate. Dried, weighed 16g, light yellow crystals, the yield was 58.7%.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55676-22-7, 3-Acetyl-6-chloropyridine, and friends who are interested can also refer to it.
Reference:
Patent; China Agricultural University; Tan Zhaohai; Yang Dongyan; (19 pag.)CN106946770; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem