Adding a certain compound to certain chemical reactions, such as: 15862-30-3, 3-Bromo-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 15862-30-3, blongs to pyridine-derivatives compound. Quality Control of 3-Bromo-5-nitropyridine
Preparation of Compound 68B: (0490) To a 25 mL flask was added (E)-tert-butyl (3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)allyl)carbamate (200 mg, 706 mumol), 3-bromo-5-nitropyridine (143 mg, 706 mumol), K2CO3 (293 mg, 2.12 mmol), dimethyl ether (4 mL), water (0.5 mL) and Pd(Ph3P)4 (81.6 mg, 70.6 mumol). Then the mixture was degassed for five times and was heated to 85 C. (oil bath) for 23 hours. The mixture was diluted with EA and water, filtered through celite. The organic layer was separated and the aqueous layer was extracted with EA. The combined organic layers were washed with brine, dried over Na2SO4 and concentrated to give a brown oil. After purification via combifalsh (eluted with EA/PE=035%), about 160 mg (E)-tert-butyl (3-(5-nitropyridin-3-yl)allyl)carbamate (Compound 68B) was obtained as yellow sticky solid. MS: calc’d 280 (M+H)+, measured 280 (M+H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-30-3, its application will become more common.
Reference:
Patent; Hoffmann-La Roche Inc.; Hoves, Sabine; Wang, Lisha; Yun, Hongying; Zhang, Weixing; Zhu, Wei; (58 pag.)US2016/257653; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem