Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 717843-48-6, name is 3-Bromo-6-methylpicolinonitrile. A new synthetic method of this compound is introduced below., Formula: C7H5BrN2
Under vacuum,Crystal water with a mass ratio of 40:60:8 g (36.1 mmol) of zinc chloride is heated to melt and remove water.Under nitrogen protection, 75 ml of 1,2-dichloroethane was added in sequence.Compound 3 is 3-bromo-6-methyl-2-cyanopyridine 5.5g(27.9mmol),13 g (77 mmol) of monomethyl malonate potassium salt and 1.8 ml (11.0 mmol) of diisopropylethylamine were stirred and refluxed for 16 hours.After the system was cooled to room temperature, 20 ml of 6N hydrochloric acid was added.Returning again for 1 hour, separating the organic phase,The aqueous phase was extracted 3 times with dichloromethane.The organic phases were combined and dried over anhydrous magnesium sulfate.Remove organic solvent, purify,The compound 4 is obtained as methyl 3-(3-bromo-6-methylpyridine)-3-carbonylpropanoate, the yield is 82%, 6.6 g;
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Reference:
Patent; Chinese Academy Of Sciences Xinjiang Physics And Chemistry Technology Institute; A Jiaikebaier·aisa; A Budula·yusupu; Huang Guozheng; Zhao Jiangyu; (20 pag.)CN108164461; (2018); A;,
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