Related Products of 36953-37-4 ,Some common heterocyclic compound, 36953-37-4, molecular formula is C5H4BrNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Sodium chloro(difluoro)acetate (5.26 g, 34.5 mmol) and potassium carbonate (0568) (3.57 g, 25.8 mmol) were added to a solution of 4-bromopyridin-2(1 /-/)-one (3.00 g, 17.2 mmol) in /V,/V-dimethylformamide (30 mL), and the reaction mixture was stirred at 95 C for 2 hours. Water (100 mL) was added, and the resulting mixture was extracted with ethyl acetate (3 x 50 mL). The combined organic layers were washed sequentially with water (200 mL) and with saturated aqueous sodium chloride solution (150 mL), dried over sodium sulfate, filtered, and concentrated in vacuo. Silica gel chromatography (Eluent: 15: 1 petroleum ether / ethyl acetate) afforded the product as a pale yellow oil. Yield: 1 .5 g, 6.7 mmol, 39%. 1H NMR (400 MHz, CDCI3) delta 8.04 (d, J=5.5 Hz, 1 H), 7.44 (t, JHF=72.6 HZ, 1 H), 7.27 (dd, J=5.4, 1 .6 Hz, 1 H), 7.12 (br d, J=1 .5 Hz, 1 H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,36953-37-4, its application will become more common.
Reference:
Patent; PFIZER INC.; ZHANG, Lei; BUTLER, Christopher Ryan; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BROWN, Matthew Frank; MCALLISTER, Laura Ann; LACHAPELLE, Erik Alphie; GILBERT, Adam Matthew; (170 pag.)WO2018/2760; (2018); A1;,
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