In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 123853-39-4, name is 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, the common compound, a new synthetic route is introduced below. COA of Formula: C16H15Cl2NO4
4-(2′,3′-dichlorophenyl)-2,6-dimethyl-5-(methoxycarbonyl)-1,4-dihydropyridin-3-carboxylic acid (20.0g, 56.2mmol), Potassium carbonate (32.lg, 232.5 mmol), lithium iodide (3.86 g, 23.2 mmol) was addedDMF (300 ml), and chloromethyl n-butyrate was added(31.6 g, 232.5 mmol) at 70 C for 4 h. The reaction solution was cooled to roomThe organic layer was separated, dried and the solvent was removed. A solid precipitated and a pale yellow solid was obtained by filtration. The filter cake was washed with 250 ml of methanol / water (100 ml)(1/1, volume ratio) to obtain 61.6 g of a solid, 87.2% yield.
The synthetic route of 123853-39-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Institute of Pharmaceutical Industry; Li J, ianqi; Zheng, Yongyong; Fang, Gan; Zhang, Li; (9 pag.)CN103242220; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem