Adding a certain compound to certain chemical reactions, such as: 22282-99-1, 4-Bromo-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 22282-99-1, blongs to pyridine-derivatives compound. Product Details of 22282-99-1
[0566] Step 1: ethyl 2-(4-bromopyridin-2-yl)acetate – To a stirred solution of 4-bromo-2-methylpyridine (1.2 g, 4.93 mmol, 1.0 eq) in THF (15 mL), was added diethyl carbonate (0.698 mL, 5.92 mmol, 1.2 eq) and the mixture stirred at -78C under nitrogen atmosphere. LDA(2′-78C for 2h. The reaction was then quenched with saturated sodium chloride solution and the product extracted with EtOAc (2′-(4-bromopyridin-2-yl)acetate (0.500 g, 30%) as a pale yellow liquid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,22282-99-1, its application will become more common.
Reference:
Patent; CAPULUS THERAPEUTICS, LLC; GREEN, Michael John; HART, Barry Patrick; (341 pag.)WO2019/148125; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem