Electric Literature of 60781-83-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.60781-83-1, name is 4-Phenylpyridin-2-amine, molecular formula is C11H10N2, molecular weight is 170.2105, as common compound, the synthetic route is as follows.
A mixture of 4-phenylpyridin-2-amine (0.4 g, 2.35 mmol) and ethyl formate (4 ml) was heated at 80C for 16 h. The reaction mixture was cooled to rt, diluted with saturated NaHC03 solution (20 ml) and extracted with DCM (3 x 15 ml). The combined organic phase was washed with water (20 ml), dried over Na2S04, filtered and concentrated under reduced pressure. The resulting crude material was purified by flash chromatography (25% EtOAc in hexane) yielding N-(4-phenylpyridin-2-yl)formamide (0.313 g, 1.58 mmol). LCMS: Method C, 1.79 min, MS: ES+ 199.14; NMR (400 MHz, DMSO-d6) delta ppm 10.74 (s, 1 H), 9.34 (d, J=10.8 Hz, 1 H), 8.39 (s, 1 H), 7.72 – 7.45 (m, 2 H), 7.48 – 7.57 (m, 3 H), 7.42 – 7.45 (m, 1 H), 7.21 (s, 1 H).
Statistics shows that 60781-83-1 is playing an increasingly important role. we look forward to future research findings about 4-Phenylpyridin-2-amine.
Reference:
Patent; MISSION THERAPEUTICS LIMITED; GIBSON, Karl Richard; JONES, Alison; KEMP, Mark Ian; MADIN, Andrew; STOCKLEY, Martin Lee; WHITLOCK, Gavin Alistair; WOODROW, Michael D.; (109 pag.)WO2017/141036; (2017); A1;,
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