Chemistry is an experimental science, HPLC of Formula: C17H15NO3, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4803-74-1, Name is 5,6-Dimethoxy-2-(pyridin-4-ylmethylene)-2,3-dihydro-1H-inden-1-one, molecular formula is C17H15NO3, belongs to pyridine-derivatives compound. In a document, author is Aliabadi, Alireza.
One-pot synthesis, crystallographic characterization, evaluation as in vitro antibacterial and cytotoxic agents of two mercury(II) complexes containing pyridine dicarboxylic acid derivatives
Two new mercury(II) complexes (C1) and (C2) were prepared through one-pot reactions of pyridine dicarboxylic acid derivatives, aminopyridine derivatives, and mercury(II) chloride metal salt. The structures of both complexes were exactly determined by X-ray crystallography. Also, studies were done by elemental and thermal analysis, FT-IR, UV-Vis, and (HNMR)-H-1 spectroscopy on them. In this research, the antibacterial effect of all compounds was evaluated against three Gram-positive bacteria namely Staphylococcus aureus, Streptococcus pyogenes and Staphylococcus epidermidis, and also three Gram-negative bacteria namely Escherichia coli, Pseudomonas aeruginosa, and Proteus vulgaris. The established antibacterial tests were including the broth microdilution method and the agar well diffusion method. S. aureus was considered as the most susceptible bacterium following treatment of the C1 (MIC=16 mu g/mL, IZD=21 mm) and C2 (MIC=32 mu g/mL, IZD=18 mm). Also, cytotoxicity of the compounds was studied in vitro using oxaliplatin as a standard by MIT assay against three cancer cell lines including human breast cancer (MCF7), human colon adenocarcinoma (HT29) and human lymphocyte (HL60). The strongest anti-proliferative effect of the Cl and C2 was exhibited toward MCF7 cells with IC50 values equal to 100 and 1 mu M, respectively. (C) 2020 Elsevier B.V. All rights reserved.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4803-74-1, in my other articles. HPLC of Formula: C17H15NO3.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem