Reference of 1256823-65-0 ,Some common heterocyclic compound, 1256823-65-0, molecular formula is C6H2BrClN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
To a mixture of 5-bromo-6-chloropicolinonitrile (5 g, 22.99 mmol) and tributyl (1-ethoxyvinyl) stannane (8.30 g, 22.99 mmol) in toluene (10 mL) was added tetrakis (triphenyl-phosphine) palladium (0) (0.531 g, 0.460 mmol) and the mixture was stirred at 110 under N2for 16h. The mixture was cooled to rt and conc. HCl (1.888 mL, 22.99 mmol) was added to the mixture. The grey mixture was stirred at 25 for 1h. The mixture was diluted with water (10 mL) and extracted with ethyl acetate (15 mL x 3) . The combined organic layers were washed with brine (10 mL x 2) , dried over sodium sulfate, filtered and the filtrate was concentrated in vacuum. The residue was purified by column chromatography (SiO2, petroleum ether: ethyl acetate from 10: 1 to 3: 1) to give the title compound.1HNMR (CDCl3, 400 MHz) delta: 7.99 (d, J 8.0 Hz, 1H) , 7.73 (d, J 7.6 Hz, 1H) , 2.72 (s, 3H) .
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1256823-65-0, 5-Bromo-6-chloropicolinonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO., LTD.; BAO, Jianming; HENDERSON, Timothy J.; LO, Michael Man-chu; MAZZOLA, JR., Robert D.; RUDD, Michael T.; TELLERS, David M.; TONG, Ling; LI, Chunsing; NA, Meng; (144 pag.)WO2019/238; (2019); A1;,
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