Adding a certain compound to certain chemical reactions, such as: 90145-48-5, 5-Bromopyridine-2-carboxamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H5BrN2O, blongs to pyridine-derivatives compound. Computed Properties of C6H5BrN2O
EXAMPLE 251 : 5-(6-(trifluoromethyl)- lH-indazol-4-yl)picolinamide [0794] A vial was charged with a mixture of 4-(4,4,5,5-tetramethyl-l ,3,2-dioxaborolan-2- yl)-6-(trifluoromethyl)-lH-indazole (0.05 g, 0.160 mmol), 5-bromopicolinamide (0.042 g, 0.208 mmol) and PdCl2(dppf) (5.86 mg, 8.01 muiotaetaomicron) in dioxane (8 mL) and aqueous saturated NaHC03 (2 mL). The resulting light brown suspension was heated at 140C for 45 minutes in a microwave reactor. The reaction mixture was subsequently concentrated and the crude residue was purified by preparative HPLC, eluting with a gradient of 25-45% ACN (containing 0.035% TFA) in H20 (containing 0.05% TFA) over a period of 6 minutes. The volatiles were removed in vacuo to give a TFA salt of the title compound as an off white solid (19 mg, 0.062 mmol, 39%). 1H NMR (400 MHz, DMSO-<) delta ppm 7.66 (s, 1 H), 7.77 (br s, 1 H), 8.06 (s, 1 H), 8.14-8.33 (m, 1 H), 8.37-8.49 (m, 1 H), 9.00-9.08 (m, 1 H), 13.84 (br s, 1 H); ESI-MS m/z [M+H]+ calc'd for Ci4H9F3N40, 307.1; found 307.15.
The synthetic route of 90145-48-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; CHERUVALLATH, Zacharia; ERICKSON, Philip; FENG, Jun; KOMANDLA, Mallareddy; LAWSON, John David; MCBRIDE, Christopher; MIURA, Joanne; MURPHY, Sean; TANG, Mingnam; TON-NU, Huong-Thu; WO2013/130855; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem