The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 824-52-2, name is 5-Methyl-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 5-Methyl-1H-pyrrolo[2,3-b]pyridine
Compound 3 (0.50 g, 3.8 mmol), methenamine (0.8 g, 5.7 mmol) was added to a three-necked flask,Water (5 mL) and acetic acid (2.5 mL);The reaction was heated to reflux for 4 hours. The reaction was cooled to room temperature and extracted with ethyl acetate (30 mL x 3); the organic phases were combined and washed with saturated brine (30 mL)Dry over sodium sulfate and filter. The filtrate was spin-dried, and the crude product was separated by silica gel column chromatography (petroleum ether: ethyl acetate = 1: 2 by volume)A pale yellow solid was obtained, compound 4 (0.3 g, 1.9 mmol, 49%)
With the rapid development of chemical substances, we look forward to future research findings about 824-52-2.
Reference:
Patent; Kanghua (Shanghai) Drug Discovery Co., Ltd.; Ma Jingxiang; (5 pag.)CN107056781; (2017); A;,
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