Adding a certain compound to certain chemical reactions, such as: 1620-77-5, 5-Methylpicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1620-77-5, blongs to pyridine-derivatives compound. SDS of cas: 1620-77-5
The compound of Example 4A (13 g, 110 mmol) is dissolved in 400 ml tetrachloro- methane, and 29.4 g (165 mmol) N-bromosuccinimide and 0.4 g (1.6 mmol) dibenzoylperoxide are added. The reaction reaction mixture is refluxed for three hours, cooled down to room temperature and filtered. The solution is washed with aqueous sodium thiosulfate, dried over magnesium sulfate, and the solvent is removed in [VACUO.] The residue is dissolved in 200 ml [DIOXANE AND] 200 ml water, calciumcarbonate (44 g, 440 mmol) is added, and the mixture is stirred at reflux for 2 hours. After cooling down to room temperature, the mixture is filtered, and dichloro- methane is added. After phase separation, the organic phase is dried over magnesium sulfate, and the solvent is removed in vacuo. The product is purified by chromato- graphy (silica, eluent [CYCLOHEXANE/ETHYL] acetate 2: 1). Yield : 5.2 g (35% [OF TH.)] [1H-NMR] (300 MHz, DMSO-d6): [8] = 4.7 (d, 2H), 5.6 (t, [1H),] 8.0 (m, 2H), 8.7 (s, 1H) ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,1620-77-5, 5-Methylpicolinonitrile, and friends who are interested can also refer to it.
Reference:
Patent; BAYER HEALTHCARE AG; WO2004/24700; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem