In 2019.0 TETRAHEDRON published article about HYPOPHOSPHITE COMBINATION SYSTEM; PHENYL SULFONE; NUCLEOPHILIC DIFLUOROMETHYLATION; CARBONYL-COMPOUNDS; SULFIDE OXIDATION; RANEY-NICKEL; REDUCTIVE DESULFURIZATION; STEREOSELECTIVE-SYNTHESIS; HIGH ENANTIOSELECTIVITY; REFORMATSKY REACTION in [Batisse, Chloe; Davila, Maria F. Cespedes; Messara, Amelia; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R.] Univ Strasbourg, Univ Haute Alsace, CNRS, ECPM,UMR LIMA 7042, 25 Rue Becquerel, F-67087 Strasbourg, France; [Castello, Marco] Univ Basilicata, Dipartimento Sci, Via Nazario Sauro 85, I-85100 Potenza, Italy; [Davila, Maria F. Cespedes; Vivet, Bertrand; Marciniak, Gilbert] Sanofi Aventis R&D, 16 Rue Ankara, F-67080 Strasbourg, France in 2019.0, Cited 143.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde
The -CHF2 moiety has shown a growing interest in pharmaceutical and agrochemical applications over the last few years. Its introduction is therefore a current research topic for organic chemists. Several groups have reported the synthesis of difluoromethylated compounds. However, the more challenging enantioselective introduction of the difluoromethyl group has been scarcely described yet. We recently developed a new strategy, based on the use of an enantiopure difluoromethyl sulfoxide used as chiral and traceless auxiliary, for the synthesis of highly enantioenriched alpha-difluoromethyl alcohols. The first method developed in our laboratory aims to access highly stereoenriched alpha,alpha-difluoro-beta-hydroxysulfoxides through the condensation of the enantiopure difluoromethyl sulfoxide on carbonyl derivatives. It is noteworthy that highly diastereo- and enantioenriched alpha,alpha-difluoro-beta-hydroxysulfoxides can also be accessed after the diastereoselective reduction of highly enantioenriched alpha,alpha-difluoro-beta-ketosulfoxides. Finally, the expected difluoromethyl-substituted alcohols can be obtained after removal of the chiral auxiliary with complete retention of stereoenrichment at carbon. (C) 2019 Elsevier Ltd. All rights reserved.
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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem