The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 8-Bromooctan-1-ol( cas:50816-19-8 ) is researched.Category: pyridine-derivatives.Leichnitz, Daniel; Pflanze, Sebastian; Beemelmanns, Christine published the article 《Stereoselective synthesis of unnatural (2S,3S)-6-hydroxy-4-sphingenine-containing sphingolipids》 about this compound( cas:50816-19-8 ) in Organic & Biomolecular Chemistry. Keywords: sphingolipid stereoselective synthesis. Let’s learn more about this compound (cas:50816-19-8).
6-Hydroxy-(4E)-sphingenine-containing sphingolipids are found in mammalian and bacterial membranes and have multiple intra- and intercellular functions. Most sphingolipids contain a (2S,3R)-2-amino-1,3-diol core structure, but only limited examples of unnatural (2S,3S)-2-amino-1,3-diol derivates have so far been reported. Using an underexplored hydrozirconation-transmetalation reaction and an unusual three-step-one-pot deprotection sequence, we were able to synthesize several unnatural (2S,3S)-6-hydroxy-(4E)-sphingenine-containing sphingolipids in only three (protected) or four (deprotected) consecutive steps, resp., including a fluorescence-labeled derivative suitable for future biol. studies.
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