As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Chloro-3-methoxypyridine
The boronic acid was prepared as described in Intermediate 5 (2. 5 mmol ; crude) and was dissolved in acetonitrile (2ML) and added to A 5ML microwave vessel. To the solution was 3. 0 mmol OF 2-CHLORO-3-METHOXYPYRIDINE (432 MG), 29 mg of tetrakis (TRIPHENYLPHOSPHINE) palladium (0). After stirring until dissolution, 7. 5 mmol of potassium carbonate (1. 06 G) was added, followed by LML of water. The mixture was then heated at 160C for 300 seconds. After reaction completion, the solvents were evaporated under vacuum. The residue was dissolved in 2N KOH and THF and heated for 10 min. After hydrolysis, the THF was evaporated and the basic layer was washed with ETOAC. The aqueous layer was then acidified and extracted 3 times with EtOAc. The organic layers were combined and washed with water and brine. After drying, filtration and evaporation, the residue was TRITERATED with ether to give the desired product as A yellow solid (310MG ; 47%). MS : MH+= 260
With the rapid development of chemical substances, we look forward to future research findings about 52605-96-6.
Reference:
Patent; RENOVIS, INC.; WO2005/32493; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem