With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.52605-96-6, name is 2-Chloro-3-methoxypyridine, molecular formula is C6H6ClNO, molecular weight is 143.57, as common compound, the synthetic route is as follows.Computed Properties of C6H6ClNO
The boronic acid was prepared as described in Intermediate 4 to give 2. 2MMOLE. (QUANT. CRUDE). The boronic acid (2. 2mmol) was dissolved in acetonitrile (2. 4M .) and 3-METHOXY-2-CHLOROPYRIDINE (380MG ; 2. 88MMO1) was added. After mixing, tetrakis palladium was added (25MG ; 0.01mol%), followed by 0. 8M . of water and KXCOS (912MG ; 6. 6MOL). The reaction mixture was heated at 160C in A Personal Chemistry EMRYS Microwave for 300S. After reaction completion, the solvents were evaporated and the residue was dissolved in EtOAc and washed with water and brine. The organic layer was dried over MGSO4, FILTERED and evaporated. The residue was then dissolved in A 1 : 1 mixture of THF/2NKOH and heated until saponification was complete. The basic layer was then extracted with EtOAc and acidified with CONC. HCI. The aqueos layer was then extracted three times with EtOAc. The combined organic layers were dried over MgSO4, filtered and evaporated to give the desired material as A beige solid (312mg ; 57%). MS : MH+= 248
At the same time, in my other blogs, there are other synthetic methods of this type of compound,52605-96-6, 2-Chloro-3-methoxypyridine, and friends who are interested can also refer to it.
Reference:
Patent; RENOVIS, INC.; WO2005/32493; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem