Adding a certain compound to certain chemical reactions, such as: 53636-56-9, Methyl 3-bromo-2-pyridinecarboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: Methyl 3-bromo-2-pyridinecarboxylate, blongs to pyridine-derivatives compound. name: Methyl 3-bromo-2-pyridinecarboxylate
A mixture of N-cyclohexyl-N-isobutyl-2-nitro-4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaboro lan-2- yl)aniline (1 .0 g, 2.5 mmol), methyl 3-bromopicolinate (594 mg, 2.75 mmol), tetrakis (144 mg, 0.125 mmol) and K2C03 (1 .04 g, 7.5 mmol) in DMF (5 mL) and H20 (1 mL) was stirred at 90C under N2 atmosphere overnight. The resulting mixture was partitioned between EtOAc and H20. The organic layer was washed with brine, dried over Na2S04, filtered and concentrated to give the crude product which was purified by flash chromatography (silica gel, 0-100% EtOAc in PE) to afford the title compound (900 mg, 91 % yield). LCMS (ESI) m/z calcd for C22H27N304: 397.20. Found: 396.12 (M-1)”.
The synthetic route of 53636-56-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DE LA ROSA, Martha Alicia; KAZMIERSKI, Wieslaw Mieczyslaw; SAMANO, Vicente; (369 pag.)WO2018/116107; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem