Synthetic Route of 5470-17-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 5470-17-7 as follows.
A mixture of 3-bromo-2-chloro-5-nitropyridine (2.37 g, 10.0 mmol) and 2,4-difluoroaniline (2.58 g, 20.0 mmol) in dimethyl sulfoxide (20 mL) was heated at 100 C for 2 hours. After cooling, the reaction mixture was partitioned between water and ethyl acetate. The organic layer was separated, and the aqueous layer was extracted with additional ethyl acetate twice. The combined organic layers were washed with saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, filtered, and concentrated. The residue was purified by flash chromatography on (silica gel, 5% ethyl acetate in heptanes) to provide the title compound (1.75 g, 53.0%). 1H NMR (400 MHz, DMSO-d6) delta 9.23 (s, 1H), 8.84 (d, J = 2.4 Hz, 1H), 8.61 (d, J = 2.4 Hz, 1H), 7.52 – 7.41 (m, 1H), 7.38 – 7.28 (m, 1H), 7.15 – 7.05 (m, 1H). MS (ESI-) m/z 328.0, 330.0 (M-H)+.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-17-7, its application will become more common.
Reference:
Article; Fidanze, Steven D.; Liu, Dachun; Mantei, Robert A.; Hasvold, Lisa A.; Pratt, John K.; Sheppard, George S.; Wang, Le; Holms, James H.; Dai, Yujia; Aguirre, Ana; Bogdan, Andrew; Dietrich, Justin D.; Marjanovic, Jasmina; Park, Chang H.; Hutchins, Charles W.; Lin, Xiaoyu; Bui, Mai H.; Huang, Xiaoli; Wilcox, Denise; Li, Leiming; Wang, Rongqi; Kovar, Peter; Magoc, Terrance J.; Rajaraman, Ganesh; Albert, Daniel H.; Shen, Yu; Kati, Warren M.; McDaniel, Keith F.; Bioorganic and Medicinal Chemistry Letters; vol. 28; 10; (2018); p. 1804 – 1810;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem