571188-59-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. A new synthetic method of this compound is introduced below.
(10) 2.25 g of the compound of formula (4) was dissolved15ml re-steamed toluene,Under nitrogen protection conditions,Add 13.5 ml (1 mol / L)Lithium hexamethyldisilazide,Reaction 30min,Then, 3 g of the compound of formula (12) (dissolved in 6 ml of reformed toluene)Reaction at low temperature for 4 hours,After the reaction is complete,Add ammonium chloride quenching,Adding methylene chloride extraction,The compound of formula (13) was purified by column chromatography
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 571188-59-5, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; East China Normal University; Hu Wenhao; Chang Huan; Xu Haiqun; Huang Haifeng; Ma Mingliang; (21 pag.)CN106749259; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem